USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: SYDC_HUMAN USC-OGP 2-DE database:  SYDC_HUMAN SYDC_HUMAN General information about the entry View entry in simple text format Entry name SYDC_HUMAN Primary accession number P14868 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Aspartate--tRNA ligase, cytoplasmic; EC=6.1.1.12; AltName: Full=Aspartyl-tRNA synthetase; Short=AspRS; AltName: Full=Cell proliferation-inducing gene 40 protein;. Gene name Name=DARS ORFNames=PIG40 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0366: pI=5.90; Mw=50591 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0670: pI=5.86; Mw=51055 Cross-references UniProtKB/Swiss-Prot P14868; SYDC_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name SYDC_HUMAN Primary accession number P14868 Secondary accession number(s) A8K3J2 D3DP77 Q2TNI3 Q32Q69 Q53HV4 Q53YC5 Q68CR9 Q9BW52 Sequence was last modified on  April 16, 2002 (version 2) Annotations were last modified on  March 15, 2017 (version 179) Name and origin of the protein Description RecName: Full=Aspartate--tRNA ligase, cytoplasmic; EC=6.1.1.12; AltName: Full=Aspartyl-tRNA synthetase; Short=AspRS; AltName: Full=Cell proliferation-inducing gene 40 protein; Gene name Name=DARS ORFNames=PIG40 Encoded on Name=DARS; ORFNames=PIG40 Keywords 3D-structure; Acetylation; Alternative splicing; Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm; Disease mutation; Ligase; Nucleotide-binding; Phosphoprotein; Polymorphism; Protein biosynthesis; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL J05032; AAA35567.1; -; mRNA EMBL AY762100; AAX07827.1; -; mRNA EMBL BT006710; AAP35356.1; -; mRNA EMBL AK290607; BAF83296.1; -; mRNA EMBL AK222476; BAD96196.1; -; mRNA EMBL CR749809; CAH18669.1; -; mRNA EMBL AC011999; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AC093391; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471058; EAX11617.1; -; Genomic_DNA EMBL CH471058; EAX11620.1; -; Genomic_DNA EMBL BC000629; AAH00629.1; -; mRNA EMBL BC107749; AAI07750.1; -; mRNA CCDS CCDS2180.1; -. [P14868-1]; . PIR A34393; SYHUDT; . RefSeq NP_001280241.1; NM_001293312.1. [P14868-2]; . RefSeq NP_001340.2; NM_001349.3. [P14868-1]; . UniGene Hs.503787; -; . UniGene Hs.595819; -; . PDB 4J15; X-ray; 2.24 A; A/B=1-501 PDBsum 4J15; -; . ProteinModelPortal P14868; -; . SMR P14868; -; . BioGrid 107984; 84; . IntAct P14868; 24; . MINT MINT-141082; -; . STRING 9606.ENSP00000264161; -; . DrugBank DB00128; L-Aspartic Acid; . iPTMnet P14868; -; . PhosphoSitePlus P14868; -; . SwissPalm P14868; -; . BioMuta DARS; -; . DMDM 20178330; -; . OGP P14868; -; . REPRODUCTION-2DPAGE IPI00216951; -; . EPD P14868; -; . MaxQB P14868; -; . PaxDb P14868; -; . PeptideAtlas P14868; -; . PRIDE P14868; -; . DNASU 1615; -; . Ensembl ENST00000264161; ENSP00000264161; ENSG00000115866. [P14868-1]; . GeneID 1615; -; . KEGG hsa:1615; -; . UCSC uc002tux.2; human. [P14868-1]; . CTD 1615; -; . DisGeNET 1615; -; . GeneCards DARS; -; . HGNC HGNC:2678; DARS; . HPA HPA020451; -; . HPA HPA029804; -; . HPA HPA029805; -; . MalaCards DARS; -; . MIM 603084; gene; . MIM 615281; phenotype; . neXtProt NX_P14868; -; . OpenTargets ENSG00000115866; -; . Orphanet 363412; Hypomyelination with brain stem and spinal cord involvement and leg spasticity; . PharmGKB PA27146; -; . eggNOG KOG0556; Eukaryota; . eggNOG COG0017; LUCA; . GeneTree ENSGT00550000074880; -; . HOVERGEN HBG001028; -; . InParanoid P14868; -; . KO K01876; -; . OMA WGDDLST; -; . OrthoDB EOG091G0530; -; . PhylomeDB P14868; -; . TreeFam TF105676; -; . BRENDA 6.1.1.12; 2681; . Reactome R-HSA-2408517; SeMet incorporation into proteins; . Reactome R-HSA-379716; Cytosolic tRNA aminoacylation; . ChiTaRS DARS; human; . GeneWiki DARS_(gene); -; . GenomeRNAi 1615; -; . PRO PR:P14868; -; . Proteomes UP000005640; Chromosome 2; . Bgee ENSG00000115866; -; . CleanEx HS_DARS; -; . ExpressionAtlas P14868; baseline and differential; . Genevisible P14868; HS; . GO GO:0005737; C:cytoplasm; TAS:ProtInc; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0004046; F:aminoacylase activity; TAS:ProtInc; . GO GO:0004815; F:aspartate-tRNA ligase activity; TAS:ProtInc; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0006422; P:aspartyl-tRNA aminoacylation; TAS:ProtInc; . GO GO:0006461; P:protein complex assembly; TAS:ProtInc; . GO GO:0006412; P:translation; TAS:ProtInc; . GO GO:0006418; P:tRNA aminoacylation for protein translation; TAS:Reactome; . HAMAP MF_02075; Asp_tRNA_synth_type2; 1; . InterPro IPR004364; aa-tRNA-synt_II; . InterPro IPR006195; aa-tRNA-synth_II; . InterPro IPR004523; Asp-tRNA_synthase_arc; . InterPro IPR002312; Asp/Asn-tRNA-synth_IIb; . InterPro IPR012340; NA-bd_OB-fold; . InterPro IPR004365; NA-bd_OB_tRNA; . Pfam PF00152; tRNA-synt_2; 1; . Pfam PF01336; tRNA_anti-codon; 1; . PRINTS PR01042; TRNASYNTHASP; . SUPFAM SSF50249; SSF50249; 1; . TIGRFAMs TIGR00458; aspS_nondisc; 1; . PROSITE PS50862; AA_TRNA_LIGASE_II; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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